The Pharmacokinetic (PK) Profile of WAKIX Supports
- Median t½ ~20 hours (7.5 to 24.2 hours) after a single 35.6-mg dose
- Median Tmax 3.5 hours (2 to 5 hours)
- No clinically significant PK differences were observed following administration with a high-fat meal
WAKIX had no clinically important PK interactions with modafinil or sodium oxybate
- In a clinical PK study to evaluate the concomitant use of WAKIX with modafinil or sodium oxybate, WAKIX had no effect on the PK of modafinil or sodium oxybate, and these agents had no clinically relevant effect on the PK of WAKIX
*Seventeen healthy male subjects received treatment with a single dose of 35.6 mg WAKIX on Day 1, modafinil 200 mg/day from Day 5 to Day 25, and a single dose of 35.6 mg WAKIX plus 200 mg modafinil on Day 26.1 †Sixteen healthy male subjects were randomized 1:1 to one of two treatment sequences: Treatment A (35.6 mg WAKIX) then Treatment B (sodium oxybate [two 2.25-g doses administered 3 hours apart] on Day 1, 35.6 mg WAKIX on Day 2, sodium oxybate [two 2.25-g doses administered 3 hours apart] on Day 3) or Treatment B then Treatment A. Treatment A and Treatment B were separated by 1 week.1
*Seventeen healthy male subjects received treatment with a single dose of 35.6 mg WAKIX on Day 1, modafinil 200 mg/day from Day 5 to Day 25, and a single dose of 35.6 mg WAKIX plus 200 mg modafinil on Day 26.1 †Sixteen healthy male subjects were randomized 1:1 to one of two treatment sequences: Treatment A (35.6 mg WAKIX) then Treatment B (sodium oxybate [two 2.25-g doses administered 3 hours apart] on Day 1, 35.6 mg WAKIX on Day 2, sodium oxybate [two 2.25-g doses administered 3 hours apart] on Day 3) or Treatment B then Treatment A. Treatment A and Treatment B were separated by 1 week.1
Some medications have clinically important drug interactions with WAKIX
Medications That Have Clinically Important Drug Interactions With WAKIX | |
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Effect of Other Drugs on WAKIX | |
Strong CYP2D6 Inhibitors |
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Strong CYP3A4 Inducers |
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Histamine 1 (H1) Antagonists |
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Drugs Known to Prolong the QT Interval |
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Effect of WAKIX on Other Drugs | |
Sensitive CYP3A4 Substrates |
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Dosing WAKIX With Other Medications
Some medications have clinically important drug interactions with WAKIX. Identify recommendations for dosing WAKIX with other medications.
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